I have been neglecting this important subject. I will include more about it here when I can, but in the meantime check out Bob Harrell's Home Page.
Both my Mac and DOS/Windows pages include support for one-handed layouts, but I haven't had a top-level link to the subject. My apologies!
...search for "Keyboard Hack".
I was using this until I found Fitaly.
Back to Introducing the Dvorak Keyboard.